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Peptide record

TPDB64823

Odorranalectin Blood-Brain Barrier standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB64823
Odorranalectin
Blood-Brain Barrier
Delivery and barrier-penetrating peptides
B3Pred Peptipedia
standard
No
A 17-aa standard natural blood-brain barrier peptide sequence curated from B3Pred and Peptipedia, with an available 3D structural model.
Chemical: Conjugated with 5(6)-carboxyfluorescein at N-termi
Sequence
YASPKSFRYPNGVLACT
Physicochemical Analysis
C85H128N22O24S1
DEQHIMW
APSY
1874.14
9.59
2
0
7
+2
-0.55
-0.206
51.76
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
2980
159.01
7
Residue Composition
number
2
A
1
R
1
N
0
D
1
C
0
E
0
Q
1
G
0
H
0
I
1
L
1
K
0
M
1
F
2
P
2
S
1
T
0
W
2
Y
1
V
Amino Acid Distribution
A: 2 R: 1 N: 1 D: 0 C: 1 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 1 K: 1 M: 0 F: 1 P: 2 S: 2 T: 1 W: 0 Y: 2 V: 1
Chemical Descriptors
17
C85H128N22O24S1
1874.14
9.59
+2
-0.55
-0.206
Conjugated with 5(6)-carboxyfluorescein at N-termi
Linear
Similarity
TyrAlaSerProLysSerPheArgTyrProAsnGlyValLeuAlaCysThr
N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CO)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CC(=O)N)C(=O)NCC(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Blood-Brain Barrier

Target

hCMEC/D3 cells

Assay & Model

2500 cells per cm square
LC/MS and Fluorescence microscopy
It shows the cellulr uptake of OL at the BBB endothelium.
Origin/Source

Source & Reference

NA
B3Pdb

Other

frog
TAT-Modified MVIIA for Crossing the Blood-Brain Barrier
Receptor-mediated transcytosis
Alone