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Peptide record

TPDB64817

CL peptide Blood-Brain Barrier standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB64817
CL peptide
Blood-Brain Barrier
Delivery and barrier-penetrating peptides
B3Pred BBPpredict Peptipedia
standard
No
A 14-aa standard natural blood-brain barrier peptide sequence curated from B3Pred, BBPpredict, and Peptipedia, with an available 3D structural model.
Sequence
RLLRLLRRRRRRRR
Physicochemical Analysis
C84H166N44O15
ANDCEQGHIKMFPSTWYV
R
2032.53
13.35
10
0
4
+10
5.86
-2.129
111.43
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
10
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
4
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 10 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 4 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
14
C84H166N44O15
2032.53
13.35
+10
5.86
-2.129
Linear
Similarity
Cationic
Evidence Records 1 records
Evidence 1 Activity

Activity

Blood-Brain Barrier

Target

MDCKII cells

Assay & Model

Confocal microscopy
CL peptide, significantly enhanced the delivery of small-molecule cargo across confluent cell monola
Origin/Source

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
It plays a synergistic role in the transcellular cargo delivery
Permeability
Combined with linker