TPDB

3D PDB MODEL

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TPDB ID TPDB64808

Peptide_Name

Neurotensin

Activity

Blood-Brain Barrier

Activity_category_statistics

Delivery and barrier-penetrating peptides

Database_Source

B3Pred BBPpredict Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 13-aa standard natural blood-brain barrier peptide sequence curated from B3Pred, BBPpredict, and Peptipedia, with an available 3D structural model.

Sequence

ELYENLPRRPYIL

FASTA

>TPDB64808|Blood-Brain Barrier|length=13
ELYENLPRRPYIL

Formula C78H122N20O21

Absent Amino Acids ADCQGHKMFSTWV

Common Amino Acids L

Mass 1675.95

PI 6.99

Basic Residues 2

Acidic Residues 2

Hydrophobic Residues 6

Net Charge -0

Boman Index 3.11

Hydrophobicity -0.723

Aliphatic Index 120.00

Half Life

Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour

Extinction Coefficient Cystines 2980

Absorbance 280nm 177.81

Polar Residues 3

number

0

A

2

R

1

N

0

D

0

C

2

E

0

Q

0

G

0

H

1

I

3

L

0

K

0

M

0

F

2

P

0

S

0

T

0

W

2

Y

0

V

Amino Acid Distribution

A: 0 R: 2 N: 1 D: 0 C: 0 E: 2 Q: 0 G: 0 H: 0 I: 1 L: 3 K: 0 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 2 V: 0

Length

13

Formula

C78H122N20O21

Mass

1675.95

PI

6.99

Net Charge

-0

Boman Index

3.11

Hydrophobicity

-0.723

Conformation

Linear

Peptide_Length

Similarity

Peptide_Sequence_3Letter

pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu

Evidence 1 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.053 min-1

Assay & Model

In Vitro Method Efflux study ICU

Animal Model Origin/Source

Response Brain elemination rate constant

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin bacterial

Transport Type Permeability

Label Direct iodination

Evidence 2 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 88.87%

Assay & Model

In Vitro Method Capillary depletion

Animal Model Origin/Source

Response % parenchyma

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin bacterial

Label Direct iodination

Evidence 3 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 11.22%

Assay & Model

In Vitro Method Capillary depletion

Animal Model Origin/Source

Response % capillary

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin bacterial

Label Direct iodination

Evidence 4 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.03383 ml/g

Assay & Model

Animal Model Origin/Source

Response Initial disrobution volume

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin bacterial

In Vivo Mode of Delivery Intravenous

Transport Type Permeability

Label Direct iodination

Evidence 5 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.00075 mL/(g x min)

Assay & Model

Animal Model Origin/Source

Response Unidirectional influx rate constant

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin bacterial

In Vivo Mode of Delivery Intravenous

Transport Type Permeability

Label Direct iodination

Evidence 6 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.01125 ml/g

Assay & Model

Animal Model Origin/Source

Response Initial disrobution volume

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin bacterial

In Vivo Mode of Delivery Intravenous

Transport Type Permeability

Label Direct iodination

In_Vivo_Mode_of_Delivery

Intravenous