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Peptide record

TPDB64797

D3 Blood-Brain Barrier standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB64797
D3
Blood-Brain Barrier
Delivery and barrier-penetrating peptides
B3Pred BBPpredict Peptipedia
standard
No
A 12-aa standard natural blood-brain barrier peptide sequence curated from B3Pred, BBPpredict, and Peptipedia, with an available 3D structural model.
Sequence
RPRTRLHTHRNR
Physicochemical Analysis
C65H114N32O16
ADCEQGIKMFSWYV
R
1599.83
13.00
7
0
1
+5
6.56
-2.633
32.50
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
3
Residue Composition
number
0
A
5
R
1
N
0
D
0
C
0
E
0
Q
0
G
2
H
0
I
1
L
0
K
0
M
0
F
1
P
0
S
2
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 5 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 2 I: 0 L: 1 K: 0 M: 0 F: 0 P: 1 S: 0 T: 2 W: 0 Y: 0 V: 0
Chemical Descriptors
12
C65H114N32O16
1599.83
13.00
+5
6.56
-2.633
Linear
Similarity
D-Arg-D-Pro-D-Arg-D-Thr-D-Arg-D-Leu-D-His-D-Thr-D-His-D-Arg-D-Asn-D-Arg
N[C@@]([H])(CCCNC(=N)N)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC1=CN=C-N1)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CC1=CN=C-N1)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)O
Evidence Records 3 records
Evidence 1 Activity

Activity

Blood-Brain Barrier
9.5 (x 10-4) cm/min

Assay & Model

Initial concentration in donor chamber-Culture
Origin/Source
Permeability index

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Saturable
Evidence 2 Activity

Activity

Blood-Brain Barrier
0.14 %/g

Assay & Model

Origin/Source
% injected dose

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Permeability
H3/C14
Evidence 3 Activity

Activity

Blood-Brain Barrier
0.8

Assay & Model

Origin/Source
Brain to plasma ratio

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Permeability
H3/C14