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Peptide record

TPDB64795

D1 Blood-Brain Barrier standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB64795
D1
Blood-Brain Barrier
Delivery and barrier-penetrating peptides
B3Pred BBPpredict Peptipedia
standard
No
A 12-aa standard natural blood-brain barrier peptide sequence curated from B3Pred, BBPpredict, and Peptipedia, with an available 3D structural model.
Sequence
QSHYRHISPAQV
Physicochemical Analysis
C62H95N21O18
NDCEGLKMFTW
QHS
1422.57
9.88
3
0
4
+1
3.25
-0.992
65.00
Mammalian: 0.8 hour Yeast: 10 min E.coli: >10 hour
1490
104.74
5
Residue Composition
number
1
A
1
R
0
N
0
D
0
C
0
E
2
Q
0
G
2
H
1
I
0
L
0
K
0
M
0
F
1
P
2
S
0
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 1 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 2 G: 0 H: 2 I: 1 L: 0 K: 0 M: 0 F: 0 P: 1 S: 2 T: 0 W: 0 Y: 1 V: 1
Chemical Descriptors
12
C62H95N21O18
1422.57
9.88
+1
3.25
-0.992
Linear
Similarity
D-Gln-D-Ser-D-His-D-Tyr-D-Arg-D-His-D-Ile-D-Ser-D-Pro-D-Ala-D-Gln-D-Val
N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC1=CN=C-N1)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CC1=CN=C-N1)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CO)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(C(C)C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Blood-Brain Barrier
3.8 (x 10-4) cm/min

Assay & Model

Initial concentration in donor chamber-Culture
Origin/Source
Permeability index

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
non saturable