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Peptide record

TPDB64789

JMV 2012 Blood-Brain Barrier standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB64789
JMV 2012
Blood-Brain Barrier
Delivery and barrier-penetrating peptides
B3Pred BBPpredict Peptipedia
standard
No
A 12-aa standard natural blood-brain barrier peptide sequence curated from B3Pred, BBPpredict, and Peptipedia, with an available 3D structural model.
Sequence
KKPYILKKPYIL
Physicochemical Analysis
C76H126N16O15
ARNDCEQGHMFSTWV
K
1503.93
10.41
4
0
6
+4
1.24
-0.400
130.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
2980
198.15
2
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
2
I
2
L
4
K
0
M
0
F
2
P
0
S
0
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 2 L: 2 K: 4 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 2 V: 0
Chemical Descriptors
12
C76H126N16O15
1503.93
10.41
+4
1.24
-0.400
Linear
Similarity
Lys-Lys-Pro-Tyr-Ile-Leu-Lys-Lys-Pro-Tyr-Ile-Leu
O=C(NC(C(=O)N1CCCC1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N3C(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)O)CC(C)C)C(C)CC)Cc2ccc(O)cc2)CCC3)CCCCN)CCCCN)CC(C)C)C(C)CC)Cc4ccc(O)cc4)CCCCN)C(N)CCCCN
Evidence Records 4 records
Evidence 1 Activity

Activity

Blood-Brain Barrier
0.00339 mL/(g x min)

Assay & Model

Origin/Source
Unidirectional flux rate constant

Source & Reference

NA
B3Pdb

Other

human,mouse,rat
in situ brain perfusion
Saturable
Direct iodination
Evidence 2 Activity

Activity

Blood-Brain Barrier
0.0267 ml/g

Assay & Model

Origin/Source
Initial distribution vaolume

Source & Reference

NA
B3Pdb

Other

human,mouse,rat
in situ brain perfusion
Permeability
Direct iodination
Evidence 3 Activity

Activity

Blood-Brain Barrier
0.000000565 cm/s

Assay & Model

Origin/Source
permiability constant

Source & Reference

NA
B3Pdb

Other

human,mouse,rat
in situ brain perfusion
Permeability
Direct iodination
Evidence 4 Activity

Activity

Blood-Brain Barrier
0.000153333 cm/s

Assay & Model

BMEC
Origin/Source
Permeability coefficient

Source & Reference

NA
B3Pdb

Other

human,mouse,rat
Saturable
Additional Detail Fields 1 fields
in situ brain perfusion