TPDB

3D PDB MODEL

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TPDB ID TPDB64785

Peptide_Name

Mtfpep

Activity

Blood-Brain Barrier

Activity_category_statistics

Delivery and barrier-penetrating peptides

Database_Source

B3Pred BBPpredict Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 12-aa standard natural blood-brain barrier peptide sequence curated from B3Pred, BBPpredict, and Peptipedia, with an available 3D structural model.

Modification

C-terminal: Polyethylene glycol (PEG)4 linker

Sequence

DSSHAFTLDELR

FASTA

>TPDB64785|Blood-Brain Barrier|length=12
DSSHAFTLDELR

Formula C59H91N17O22

Absent Amino Acids NCQGIKMPWYV

Common Amino Acids DLS

Mass 1390.47

PI 4.30

Basic Residues 2

Acidic Residues 3

Hydrophobic Residues 4

Net Charge -2

Boman Index 4.23

Hydrophobicity -0.692

Aliphatic Index 73.33

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 3

number

1

A

1

R

0

N

2

D

0

C

1

E

0

Q

0

G

1

H

0

I

2

L

0

K

0

M

1

F

0

P

2

S

1

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 1 R: 1 N: 0 D: 2 C: 0 E: 1 Q: 0 G: 0 H: 1 I: 0 L: 2 K: 0 M: 0 F: 1 P: 0 S: 2 T: 1 W: 0 Y: 0 V: 0

Length

12

Formula

C59H91N17O22

Mass

1390.47

PI

4.30

Net Charge

-2

Boman Index

4.23

Hydrophobicity

-0.692

C_terminal_Modification

Polyethylene glycol (PEG)4 linker

Conformation

Linear

Peptide_Length

Similarity

Peptide_Sequence_3Letter

AspSerSerHisAlaPheThrLeuAspGluLeuArg

SMILES

N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC1=CN=C-N1)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)O

Evidence 1 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 5.5 days

Assay & Model

Animal Model Origin/Source

In Vivo Concentration 2 MTfpep per NIP228 antibody

In Vivo Method 3D confocal fluorescence microscopy

In Vivo Result Two times greater fractional fluorescence was measured in the brain parenchyma.

Physical Condition Neuropathic pain

Response Stability/half life

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Melanotransferrin

In Vivo Mode of Delivery Intravenous

BBB Action It delivers a protein-based interleukin 1 receptor antagonist across the BBB and ameliorates

Transport Type Transcytosis

Subcellular Localisation Surface of normal brain endothelial cells, the main constituent of the BBB, and is able to cross thr

Combination Successfully delivers therapeutic amounts of an an

In_Vivo_Mode_of_Delivery

Intravenous