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Peptide record

TPDB64782

C2-9r Blood-Brain Barrier standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB64782
C2-9r
Blood-Brain Barrier
Delivery and barrier-penetrating peptides
B3Pred Peptipedia
standard
No
A 12-aa standard natural blood-brain barrier peptide sequence curated from B3Pred and Peptipedia, with an available 3D structural model.
C-terminal: 4 Gly (G) and nine d-Arg (9r) residues to the Cter Chemical: Coupled with a 9-amiNA acid arginine linker
Sequence
CDIFTNSRGKRA
Physicochemical Analysis
C56H94N20O18S1
EQHLMPWYV
R
1367.55
10.10
3
1
3
+2
2.69
-0.850
40.83
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
4
Residue Composition
number
1
A
2
R
1
N
1
D
1
C
0
E
0
Q
1
G
0
H
1
I
0
L
1
K
0
M
1
F
0
P
1
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 2 N: 1 D: 1 C: 1 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 0 K: 1 M: 0 F: 1 P: 0 S: 1 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
12
C56H94N20O18S1
1367.55
10.10
+2
2.69
-0.850
4 Gly (G) and nine d-Arg (9r) residues to the Cter
Coupled with a 9-amiNA acid arginine linker
Similarity
CysAspIlePheThrAsnSerArgGlyLysArgAla
N[C@@]([H])(CS)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Blood-Brain Barrier

Target

Mouse cholinergic cell line Neuro2A (N2A)

Assay & Model

100000 cells/well
Laser scanning confocal microscopy
It crosses the BBB with conguagted siRNA for alpha-syn.
Origin/Source
50 microgram
Laser scanning confocal microscopy
It can transport siα-syn across the BBB as a therapeutic option for synucleinopathies.
Lewy body disease

Source & Reference

NA
B3Pdb

Other

rhabdovirus glycoprotein
Intraperitoneal
It showed reduced accumulation of α-syn associated with amelioration of the neurodegenerative and i
Neurons and glial cellsexhibiting α-syn accumulation
Combined with siRNA for alpha-syn
Additional Detail Fields 1 fields
Intraperitoneal