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Peptide record

TPDB64781

PHT-TGN-HBc Blood-Brain Barrier standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB64781
PHT-TGN-HBc
Blood-Brain Barrier
Delivery and barrier-penetrating peptides
B3Pred BBPpredict Peptipedia
standard
No
A 12-aa standard natural blood-brain barrier peptide sequence curated from B3Pred, BBPpredict, and Peptipedia, with an available 3D structural model.
Sequence
TGNYKALHPHNG
Physicochemical Analysis
C57H85N19O17
RDCEQIMFSWV
NGH
1308.42
9.74
3
0
3
+1
2.69
-1.342
40.83
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
1490
113.88
4
Residue Composition
number
1
A
0
R
2
N
0
D
0
C
0
E
0
Q
2
G
2
H
0
I
1
L
1
K
0
M
0
F
1
P
0
S
1
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 2 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 2 I: 0 L: 1 K: 1 M: 0 F: 0 P: 1 S: 0 T: 1 W: 0 Y: 1 V: 0
Chemical Descriptors
12
C57H85N19O17
1308.42
9.74
+1
2.69
-1.342
Linear
Similarity
Evidence Records 1 records
Evidence 1 Activity

Activity

Blood-Brain Barrier
It efficiently target the brain tissue by 2.4 fold and increase the antiepileptic efficiency of phen

Target

Human astrocytes HA1800

Assay & Model

0.2 mg PHT/kg
Confocal Microscopy
Origin/Source
0.2 mg PHT/kg
VIS Lumina II Spectrum Imaging System
It demonstrated high penetration ability
Refractory Epilepsy
It prolongs the circulation time of the drug and efficiently load large amount of drugs, and showed

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Intravenous
PHT-TGN-HBc NCs showed high antiepileptic effects in epilepsy mouse model with no side effects
Permeability
Cerebral vasculature
Comined with phenytoin and hepatitis B core
Additional Detail Fields 1 fields
Intravenous