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Peptide record

TPDB64777

ApoB11 Blood-Brain Barrier standard
11 amino acids
Basic Information
3D PDB MODEL
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TPDB64777
ApoB11
Blood-Brain Barrier
Delivery and barrier-penetrating peptides
B3Pred Peptipedia
standard
No
A 11-aa standard natural blood-brain barrier peptide sequence curated from B3Pred and Peptipedia, with an available 3D structural model.
C-terminal: 5 Gly (G) and 9 Arg (R) amino acids to the C-termi Chemical: Coupled with a 9-amiNA acid arginine linker
Sequence
RLTRKRGLKLA
Physicochemical Analysis
C57H110N22O13
NDCEQHIMFPSWYV
RL
1311.64
12.71
5
0
4
+5
2.71
-0.836
115.45
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
1
Residue Composition
number
1
A
3
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
3
L
2
K
0
M
0
F
0
P
0
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 3 K: 2 M: 0 F: 0 P: 0 S: 0 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
11
C57H110N22O13
1311.64
12.71
+5
2.71
-0.836
5 Gly (G) and 9 Arg (R) amino acids to the C-termi
Coupled with a 9-amiNA acid arginine linker
Similarity
ArgLeuThrArgLysArgGlyLeuLysLeuAla
N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)NCC(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Blood-Brain Barrier

Target

Mouse cholinergic cell line Neuro2A (N2A)

Assay & Model

100000 cells/well
Laser scanning confocal microscopy
It crosses the BBB with conguagted siRNA for alpha-syn.
Origin/Source
50 microgram
Laser scanning confocal microscopy
It can transport siα-syn across the BBB as a therapeutic option for synucleinopathies.
Lewy body disease

Source & Reference

NA
B3Pdb

Other

ApoB38 peptide
Intraperitoneal
It showed reduced accumulation of α-syn associated with amelioration of the neurodegenerative and i
Neurons and glial cellsexhibiting α-syn accumulation
Combined with siRNA for alpha-syn
Additional Detail Fields 1 fields
Intraperitoneal