TPDB

3D PDB MODEL

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TPDB ID TPDB64773

Peptide_Name

N-Tyr-Delta Sleep In

Activity

Blood-Brain Barrier

Activity_category_statistics

Delivery and barrier-penetrating peptides

Database_Source

B3Pred BBPpredict Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 10-aa standard natural blood-brain barrier peptide sequence curated from B3Pred, BBPpredict, and Peptipedia, with an available 3D structural model.

Sequence

YWAGGDASGE

FASTA

>TPDB64773|Blood-Brain Barrier|length=10
YWAGGDASGE

Formula C44H57N11O17

Absent Amino Acids RNCQHILKMFPTV

Common Amino Acids G

Mass 1012.00

PI 3.01

Basic Residues 0

Acidic Residues 2

Hydrophobic Residues 4

Net Charge -2

Boman Index 0.28

Hydrophobicity -0.760

Aliphatic Index 20.00

Half Life

Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min

Extinction Coefficient Cystines 6990

Absorbance 280nm 690.71

Polar Residues 2

number

2

A

0

R

0

N

1

D

0

C

1

E

0

Q

3

G

0

H

0

I

0

L

0

K

0

M

0

F

0

P

1

S

0

T

1

W

1

Y

0

V

Amino Acid Distribution

A: 2 R: 0 N: 0 D: 1 C: 0 E: 1 Q: 0 G: 3 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 1 T: 0 W: 1 Y: 1 V: 0

Length

10

Formula

C44H57N11O17

Mass

1012.00

PI

3.01

Net Charge

-2

Boman Index

0.28

Hydrophobicity

-0.760

Conformation

Linear

Peptide_Length

Similarity

Peptide_Sequence_3Letter

Tyr-Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu

SMILES

C[C@@H](C(=O)NCC(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)O)NC(=O)[C@H](CC1=CNC2=CC=CC=C21)NC(=O)[C@H](CC3=CC=C(C=C3)O)N

Evidence 1 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.18 %/g

Assay & Model

Animal Model Origin/Source

Response % injected dose

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin synthetic,viral

In Vivo Mode of Delivery Intracarotid injection

Transport Type Permeability

Label Direct iodination

Evidence 2 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.22 %/g

Assay & Model

Animal Model Origin/Source

Response % injected dose

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin synthetic,viral

In Vivo Mode of Delivery Intracarotid injection

Transport Type Permeability

Label Direct iodination

Evidence 3 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.00556

Assay & Model

Animal Model Origin/Source

Response Brain to plasma ratio

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin synthetic,viral

In Vivo Mode of Delivery Intracarotid injection

Transport Type Permeability

Label Direct iodination

Evidence 4 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.00275

Assay & Model

Animal Model Origin/Source

Response Brain to plasma ratio

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin synthetic,viral

In Vivo Mode of Delivery Intracarotid injection

Transport Type Permeability

Label Direct iodination

Evidence 5 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 116

Assay & Model

Animal Model Origin/Source

Response Blood/brain ratio

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin synthetic,viral

In Vivo Mode of Delivery Intracarotid injection

Transport Type Permeability

Label Direct iodination

In_Vivo_Mode_of_Delivery

Intracarotid injection