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Peptide record

TPDB64761

NR2B9c Blood-Brain Barrier standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB64761
NR2B9c
Blood-Brain Barrier
Delivery and barrier-penetrating peptides
B3Pred BBPpredict Peptipedia
standard
No
A 9-aa standard natural blood-brain barrier peptide sequence curated from B3Pred, BBPpredict, and Peptipedia, with an available 3D structural model.
Sequence
KLSSIESDV
Physicochemical Analysis
C41H72N10O17
ARNCQGHMFPTWY
S
977.08
4.07
1
2
3
-1
3.83
-0.089
118.89
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
3
Residue Composition
number
0
A
0
R
0
N
1
D
0
C
1
E
0
Q
0
G
0
H
1
I
1
L
1
K
0
M
0
F
0
P
3
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 1 C: 0 E: 1 Q: 0 G: 0 H: 0 I: 1 L: 1 K: 1 M: 0 F: 0 P: 0 S: 3 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
9
C41H72N10O17
977.08
4.07
-1
3.83
-0.089
Similarity
LysLeuSerSerIleGluSerAspVal
N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(C(C)C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Blood-Brain Barrier

Assay & Model

Origin/Source
HPLC-MS/MS
NR2B9c-WGA-NPs are able to bypass the BBB and effectively transport NR2B9c into the brain and neuron
ischemic stroke

Source & Reference

NA
B3Pdb

Other

Intranasal
It can protect neurons against excitotoxicity, reduce ischemic brain injury and ameliorate neurologi
Transcytosis
NR2B9c is combined with WGA-modified nanoparticles
Additional Detail Fields 1 fields
Intranasal