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Peptide record

TPDB64758

AP9 Blood-Brain Barrier standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB64758
AP9
Blood-Brain Barrier
Delivery and barrier-penetrating peptides
B3Pred BBPpredict Peptipedia
standard
No
A 9-aa standard natural blood-brain barrier peptide sequence curated from B3Pred, BBPpredict, and Peptipedia, with an available 3D structural model.
C-terminal: C-terminal amidation
Sequence
NPNDKYEPF
Physicochemical Analysis
C51H70N12O17
ARCQGHILMSTWV
NP
1123.19
4.07
1
2
2
-1
3.91
-2.178
0.00
Mammalian: 1.4 hour Yeast: 3 min E.coli: >10 hour
1490
132.66
3
Residue Composition
number
0
A
0
R
2
N
1
D
0
C
1
E
0
Q
0
G
0
H
0
I
0
L
1
K
0
M
1
F
2
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 2 D: 1 C: 0 E: 1 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 1 M: 0 F: 1 P: 2 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
9
C51H70N12O17
1123.19
4.07
-1
3.91
-2.178
C-terminal amidation
Linear
Similarity
Evidence Records 1 records
Evidence 1 Activity

Activity

Blood-Brain Barrier

Assay & Model

Origin/Source
20 mg/kg
Evans blue dye
The preservation of the protective effect of double AP9 administration in the postischemic period.
Photothrombosis - induced ischemia

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Intravenous
It induce β-arrestin-2-dependent cytoprotective pathways.
Alone
Additional Detail Fields 1 fields
Intravenous