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Peptide record

TPDB64750

D-T7 Blood-Brain Barrier standard
8 amino acids
Basic Information
3D PDB MODEL
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TPDB64750
D-T7
Blood-Brain Barrier
Delivery and barrier-penetrating peptides
B3Pred BBPpredict Peptipedia
standard
No
A 8-aa standard natural blood-brain barrier peptide sequence curated from B3Pred, BBPpredict, and Peptipedia, with an available 3D structural model.
C-terminal: Cysteine on C-terminal
Sequence
HRPYIAHC
Physicochemical Analysis
C44H65N15O10S1
NDEQGLKMFSTWV
H
996.15
8.91
3
0
3
+1
1.52
-0.625
61.25
Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour
1490
149.58
2
Residue Composition
number
1
A
1
R
0
N
0
D
1
C
0
E
0
Q
0
G
2
H
1
I
0
L
0
K
0
M
0
F
1
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 0 H: 2 I: 1 L: 0 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
8
C44H65N15O10S1
996.15
8.91
+1
1.52
-0.625
Cysteine on C-terminal
Linear
Similarity
HisArgProTyrIleAlaHisCys
N[C@@]([H])(CC1=CN=C-N1)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC1=CN=C-N1)C(=O)N[C@@]([H])(CS)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Blood-Brain Barrier
3.31-fold higher than saline

Target

bEnd.3 and c6 cells

Assay & Model

Confocal microscopy
It crosses the BBB.
Origin/Source
PTX-1.7 mg/kg, CD-3.6 mg/kg
Glioma
Stability/half life

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Intravenous
D-T7 Peptide Modified PEGylated Bilirubin Nanoparticles Loaded with Cediranib and Paclitaxel for Ant
Combined with Cediranib and Paclitaxel.
Additional Detail Fields 1 fields
Intravenous