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Peptide record

TPDB64732

SLS SLSHSPQ Blood-Brain Barrier standard
7 amino acids
Basic Information
3D PDB MODEL
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TPDB64732
SLS SLSHSPQ
Blood-Brain Barrier
Delivery and barrier-penetrating peptides
B3Pred BBPpredict Peptipedia
standard
No
A 7-aa standard natural blood-brain barrier peptide sequence curated from B3Pred, BBPpredict, and Peptipedia, with an available 3D structural model.
Sequence
SLSHSPQ
Physicochemical Analysis
C31H50N10O12
ARNDCEGIKMFTWYV
S
754.80
7.85
1
0
1
+0
1.82
-0.986
55.71
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
4
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
1
Q
0
G
1
H
0
I
1
L
0
K
0
M
0
F
1
P
3
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 1 I: 0 L: 1 K: 0 M: 0 F: 0 P: 1 S: 3 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
7
C31H50N10O12
754.80
7.85
+0
1.82
-0.986
Cyclic Linear
Similarity
Neutral
SerLeuSerHisSerProGln Ser - Leu - Ser - His - Ser - Pro - Gln
N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC1=CN=C-N1)C(=O)N[C@@]([H])(CO)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)O
Evidence Records 2 records
Evidence 1 Activity

Activity

Blood-Brain Barrier

Target

hCMEC/D3 cell monolayers

Assay & Model

200000 cells per well
Confocal microscopy
It promoted phage permeation across the hCMEC/D3 cell monolayer.
Origin/Source
Plaque formation assay
Cyclic SLS peptide facilitated phage permeation across the mouse BBB in vivo

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Intravenous
BBB-permeable cyclic SLS heptapeptide for brain delivery of macromolecules via macropinocytosis and
Macropinocytosis
Brain parenchyma
Combined with M13 phage
Evidence 2 Activity

Activity

Blood-Brain Barrier

Assay & Model

Origin/Source

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Additional Detail Fields 1 fields
Intravenous