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Peptide record

TPDB64730

ADTC5 Blood-Brain Barrier standard
7 amino acids
Basic Information
3D PDB MODEL
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TPDB64730
ADTC5
Blood-Brain Barrier
Delivery and barrier-penetrating peptides
B3Pred BBPpredict Peptipedia
standard
No
A 7-aa standard natural blood-brain barrier peptide sequence curated from B3Pred, BBPpredict, and Peptipedia, with an available 3D structural model.
C-terminal: Amide group is attached at C-terminal
Sequence
CDTPPVC
Physicochemical Analysis
C29H47N7O11S2
ARNEQGHILKMFSWY
CP
733.85
3.10
0
1
1
-1
1.86
0.257
41.43
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
125
17.03
3
Residue Composition
number
0
A
0
R
0
N
1
D
2
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
2
P
0
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 1 C: 2 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 2 S: 0 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
7
C29H47N7O11S2
733.85
3.10
-1
1.86
0.257
Amide group is attached at C-terminal
Cyclic
Similarity
CysAspThrProProValCys
N[C@@]([H])(CS)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CS)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Blood-Brain Barrier

Assay & Model

Origin/Source
Mass Spectromtery
It is able to deliver an IRdye800CW-labeled IgG monoclonal antibody into the brain.

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Intracerebral ventricular
Synthesized novel cyclic peptides are able efectively modulate the BBB to enhance the delivery of mA
Combined with monoclonal antibody
Additional Detail Fields 1 fields
Intracerebral ventricular