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Peptide record

TPDB64724

HAVN1 Blood-Brain Barrier standard
6 amino acids
Basic Information
3D PDB MODEL
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TPDB64724
HAVN1
Blood-Brain Barrier
Delivery and barrier-penetrating peptides
B3Pred BBPpredict Peptipedia
standard
No
A 6-aa standard natural blood-brain barrier peptide sequence curated from B3Pred, BBPpredict, and Peptipedia, with an available 3D structural model.
Sequence
SHAVSS
Physicochemical Analysis
C23H38N8O10
RNDCEQGILKMFPTWY
S
586.60
7.85
1
0
2
+0
1.25
0.067
65.00
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
3
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
1
H
0
I
0
L
0
K
0
M
0
F
0
P
3
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 3 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
6
C23H38N8O10
586.60
7.85
+0
1.25
0.067
Cyclic
Similarity
SerHisAlaValSerSer
N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC1=CN=C-N1)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CO)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Blood-Brain Barrier

Assay & Model

Origin/Source
Mass Spectromtery
It is able to deliver an IRdye800CW-labeled IgG monoclonal antibody into the brain.

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Intracerebral ventricular
Synthesized novel cyclic peptides are able efectively modulate the BBB to enhance the delivery of mA
Combined with monoclonal antibody
Additional Detail Fields 1 fields
Intracerebral ventricular