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Peptide record

TPDB64717

P18 P21 Blood-Brain Barrier standard
6 amino acids
Basic Information
3D PDB MODEL
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TPDB64717
P18 P21
Blood-Brain Barrier
Delivery and barrier-penetrating peptides
B3Pred BBPpredict Peptipedia
standard
No
A 6-aa standard natural blood-brain barrier peptide sequence curated from B3Pred, BBPpredict, and Peptipedia, with an available 3D structural model.
C-terminal: C-terminal amidation
Sequence
VQIVYK
Physicochemical Analysis
C36H60N8O9
ARNDCEGHLMFPSTW
V
748.92
9.74
1
0
4
+1
0.46
0.700
161.67
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
1490
198.95
2
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
1
Q
0
G
0
H
1
I
0
L
1
K
0
M
0
F
0
P
0
S
0
T
0
W
1
Y
2
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 1 L: 0 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 2
Chemical Descriptors
6
C36H60N8O9
748.92
9.74
+1
0.46
0.700
C-terminal amidation
Linear
Similarity
Evidence Records 2 records
Evidence 1 Activity

Activity

Blood-Brain Barrier
These peptide-based modulators (Trojans) were non-amyloidogenic, stable in serum and showed minimal

Target

Human brain endothelial cells (EA.hy926)

Assay & Model

Field-emission transmission electron microscope
A3 peptide treated with this peptide, showed higher folds of decrease in fluorescence intensities a
Origin/Source
Tauopathies
These peptides were capable of reducing the tau elicit toxicity by accelerating or impeding the self

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Trojan peptides are capable of translo- cating the BBB, without affecting its interity.
Translocation
Comined with A3 pepide
Evidence 2 Activity

Activity

Blood-Brain Barrier
These peptide-based modulators (Trojans) were non-amyloidogenic, stable in serum and showed minimal

Target

Human brain endothelial cells (EA.hy926)

Assay & Model

Field-emission transmission electron microscope
A3 peptide treated with this peptide, showed higher folds of decrease in fluorescence intensities a
Origin/Source
Tauopathies
These peptides were capable of reducing the tau elicit toxicity by accelerating or impeding the self

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Trojan peptides are capable of translo- cating the BBB, without affecting its interity.
Translocation
Comined with A3 pepide