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Peptide record

TPDB64709

HAVN2 Blood-Brain Barrier standard
5 amino acids
Basic Information
3D PDB MODEL
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TPDB64709
HAVN2
Blood-Brain Barrier
Delivery and barrier-penetrating peptides
B3Pred BBPpredict Peptipedia
standard
No
A 5-aa standard natural blood-brain barrier peptide sequence curated from B3Pred, BBPpredict, and Peptipedia, with an available 3D structural model.
Sequence
SHAVS
Physicochemical Analysis
C20H33N7O8
RNDCEQGILKMFPTWY
S
499.52
7.85
1
0
2
+0
1.12
0.240
78.00
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
2
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
1
H
0
I
0
L
0
K
0
M
0
F
0
P
2
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 2 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
5
C20H33N7O8
499.52
7.85
+0
1.12
0.240
Cyclic
Similarity
SerHisAlaValSer
N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC1=CN=C-N1)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CO)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Blood-Brain Barrier

Assay & Model

Origin/Source
Mass Spectromtery
It is able to deliver an IRdye800CW-labeled IgG monoclonal antibody into the brain.

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Intracerebral ventricular
Synthesized novel cyclic peptides are able efectively modulate the BBB to enhance the delivery of mA
Combined with monoclonal antibody
Additional Detail Fields 1 fields
Intracerebral ventricular