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Peptide record

TPDB64703

CC-TN-APNPs Blood-Brain Barrier standard
5 amino acids
Basic Information
3D PDB MODEL
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TPDB64703
CC-TN-APNPs
Blood-Brain Barrier
Delivery and barrier-penetrating peptides
B3Pred BBPpredict Peptipedia
standard
No
A 5-aa standard natural blood-brain barrier peptide sequence curated from B3Pred, BBPpredict, and Peptipedia, with an available 3D structural model.
Sequence
CCAQK
Physicochemical Analysis
C20H37N7O7S2
RNDEGHILMFPSTWYV
C
551.68
8.29
1
0
1
+1
0.92
-0.120
20.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
125
22.66
3
Residue Composition
number
1
A
0
R
0
N
0
D
2
C
0
E
1
Q
0
G
0
H
0
I
0
L
1
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 2 E: 0 Q: 1 G: 0 H: 0 I: 0 L: 0 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
5
C20H37N7O7S2
551.68
8.29
+1
0.92
-0.120
Linear
Similarity
CysCysAlaGlnLys
N[C@@]([H])(CS)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Blood-Brain Barrier

Target

hCMEC/D3 and NHA cells

Assay & Model

TEM imaging
Responsive to thrombin cleavage, reduced the cytotoxicity of Tat-NR2B9c, and increased BBB permeabil
Origin/Source
Dynamic light scattering
Better circulation time, better targeting ability and penetrating efficiency to the injured brain, a
Traumatic brain injury

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Intravenous
Treatment reduced the injury size
Combined with Tat-NR2B9c
Additional Detail Fields 1 fields
Intravenous