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Peptide record

TPDB64691

peptide 1b(Trithiol bicycle) peptide 1nfb(Non-fluorinated bicycle) Cell-penetrating Peptides modified_plain modified
16 amino acids
Basic Information
3D PDB MODEL
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TPDB64691
peptide 1b(Trithiol bicycle) peptide 1nfb(Non-fluorinated bicycle)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
modified_plain
Yes
A 16-aa modified cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation Chemical: Z= 4-pentynoyl
Sequence
ZCRRRRRRCRRRRRRC-NH2
Physicochemical Analysis
C81H161N51O16S3
ANDEQGHILKMFPSTWYV
R
2201.68
12.70
12
0
0
+12
9.00
-2.906
0.00
Mammalian: Yeast: E.coli:
125
5.68
3
Residue Composition
number
0
A
12
R
0
N
0
D
3
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 12 N: 0 D: 0 C: 3 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
16
C81H161N51O16S3
2201.68
12.70
+12
9.00
-2.906
Amidation
Z= 4-pentynoyl
Modified
Bicyclic
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 2 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa-654 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Bicyclic Modified
Synthetic
PMO IVS2-654
Nucleus
At 5 μM, the perfluoroaryl cyclic and bicyclic peptide conjugates all led to an approximately 14-fold increase in eGFP fluorescence relative to unconjugate PMO.
In vitro
CCSSSCCTTCCCCCSCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

HeLa-654 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Non-natural residues Bicyclic Modified
Synthetic
PMO IVS2-655
Nucleus
Exhibited lower fluorescence at 5 μM.
In vitro
Additional Detail Fields 1 fields
CCSSSCCTTCCCCCSCC