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Peptide record

TPDB64690

3b (Double macrocycle) Cell-penetrating Peptides modified_plain modified
17 amino acids
Basic Information
3D PDB MODEL
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TPDB64690
3b (Double macrocycle)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
modified_plain
Yes
A 17-aa modified cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation Chemical: Z= 4-pentynoyl
Sequence
ZCRRRRRRCCRRRRRRC-NH2
Physicochemical Analysis
C84H166N52O17S4
ANDEQGHILKMFPSTWYV
R
2304.82
12.55
12
0
0
+12
8.76
-2.588
0.00
Mammalian: Yeast: E.coli:
250
10.85
4
Residue Composition
number
0
A
12
R
0
N
0
D
4
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 12 N: 0 D: 0 C: 4 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
17
C84H166N52O17S4
2304.82
12.55
+12
8.76
-2.588
Amidation
Z= 4-pentynoyl
Modified
Cyclic
Free
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa-654 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Cyclic Modified
Synthetic
PMO IVS2-657
Nucleus
At 2 μM concentration, conjugate PMO-3b outperformed all of the other conjugates showing highest fluorescence.
In vitro