Back to search

Peptide record

TPDB64689

2b (Trithiol bicycle) Cell-penetrating Peptides modified_plain modified
10 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB64689
2b (Trithiol bicycle)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
modified_plain
Yes
A 10-aa modified cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation Chemical: Z= 4-pentynoyl
Sequence
ZCRRRCRRRC-NH2
Physicochemical Analysis
C45H89N27O10S3
ANDEQGHILKMFPSTWYV
R
1264.56
12.10
6
0
0
+6
4.14
-1.950
0.00
Mammalian: Yeast: E.coli:
125
9.88
3
Residue Composition
number
0
A
6
R
0
N
0
D
3
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 3 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
10
C45H89N27O10S3
1264.56
12.10
+6
4.14
-1.950
Amidation
Z= 4-pentynoyl
Modified
Bicyclic
Free
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa-654 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Bicyclic Modified
Synthetic
PMO IVS2-656
Nucleus
At 5 μM, the perfluoroaryl cyclic and bicyclic peptide conjugates all led to an approximately 14-fold increase in eGFP fluorescence relative to unconjugate PMO.
In vitro