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Peptide record

TPDB64687

LAH4-A1-Tyr2 Cell-penetrating Peptides standard
28 amino acids
Basic Information
3D PDB MODEL
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TPDB64687
LAH4-A1-Tyr2
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 28-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation
Sequence
YYKKALLAHALHLLAALALHLAHLLKKA-NH2
Physicochemical Analysis
C150H246N40O31
RNDCEQGIMFPSTWV
L
3105.85
10.41
8
0
20
+4
-1.04
0.764
167.86
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
2980
95.95
2
Residue Composition
number
8
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
4
H
0
I
10
L
4
K
0
M
0
F
0
P
0
S
0
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 8 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 4 I: 0 L: 10 K: 4 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 2 V: 0
Chemical Descriptors
28
C150H246N40O31
3105.85
10.41
+4
-1.04
0.764
Amidation
L
Cationic and amphipathic
Linear
Free
N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Hek293T Cells And U87 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic and amphipathic
Synthetic
pSMD2LucΔITR and FLuc mRNA , EGFP mRNA , Cyanine 5 Fluc mRNA
Less efficient than the parent peptide LAH4-A1 when using NaCl, the transfection efficiency of the LAH4-A1-Tyr2 and LAH4-A1-Sali modified peptides was strongly improved when mRNA complexation occurred in a phosphate buffer pH 6.25
In vitro
CCSCCTTTCCTTTCCHHHHHTC
Additional Detail Fields 1 fields
CCSCCTTTCCTTTCCHHHHHTC