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Peptide record

TPDB64684

BBBpS_6 Cell-penetrating Peptides standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB64684
BBBpS_6
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CellPPD-MOD CPPsite3.0 Peptipedia PerseuCPP
standard
No
A 21-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD, CellPPD-MOD, CPPsite3.0, and other sources, with an available 3D structural model.
C-terminal: Amidation N-terminal: Conjugated with CF
Sequence
YTQDFNKFHTFPQTAIGVGAP-NH2
Physicochemical Analysis
C109H155N27O31
RCELMSW
FT
2339.59
7.75
2
1
8
+0
1.19
-0.371
41.90
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
1490
63.69
7
Residue Composition
number
2
A
0
R
1
N
1
D
0
C
0
E
2
Q
2
G
1
H
1
I
0
L
1
K
0
M
3
F
2
P
0
S
3
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 2 R: 0 N: 1 D: 1 C: 0 E: 0 Q: 2 G: 2 H: 1 I: 1 L: 0 K: 1 M: 0 F: 3 P: 2 S: 0 T: 3 W: 0 Y: 1 V: 1
Chemical Descriptors
21
C109H155N27O31
2339.59
7.75
+0
1.19
-0.371
Amidation
L
Hydrophobic
Linear
Conjugated with CF
N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Hebc-5I, Hs68, HeLa, MDA-MB-231 And Hek-293 Cells

Assay & Model

7-weeks old CD1 female mice
7-weeks old CD1 female mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Hydrophobic
Synthetic
CF dye and Ga-radiolabed for in-vivo
Translocation =35.6 ± 3.9 . Lowest uptakes (RFI<10.0).
In vitro and in vivo
CCCCCSSSCCC
Additional Detail Fields 1 fields
CCCCCSSSCCC