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Peptide record

TPDB64680

RVG Blood-Brain Barrier Cell-penetrating Peptides standard
29 amino acids
Basic Information
3D PDB MODEL
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TPDB64680
RVG
Blood-Brain Barrier Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
BBPpredict Peptipedia CPPsite3.0
standard
No
A 29-aa standard natural multi-activity (Blood-Brain Barrier and Cell-penetrating Peptides) peptide sequence curated from BBPpredict, Peptipedia, and CPPsite3.0, with an available 3D structural model.
Sequence
YTIWMPENPRPGTPCDIFTNSRGKRASNG
Physicochemical Analysis
C141H217N43O43S2
QHLV
P
3266.66
9.76
4
2
7
+2
5.26
-1.048
30.34
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
6990
213.98
10
Residue Composition
number
1
A
3
R
3
N
1
D
1
C
1
E
0
Q
3
G
0
H
2
I
0
L
1
K
1
M
1
F
4
P
2
S
3
T
1
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 3 N: 3 D: 1 C: 1 E: 1 Q: 0 G: 3 H: 0 I: 2 L: 0 K: 1 M: 1 F: 1 P: 4 S: 2 T: 3 W: 1 Y: 1 V: 0
Chemical Descriptors
29
C141H217N43O43S2
3266.66
9.76
+2
5.26
-1.048
Free
L
Cationic
Linear
Free
N[C@@H](CS)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O
Evidence Records 2 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Bbecs Or Rat Astrocytes And Intestine (Caco-2 Assay) And A Bbb Model

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Linear L
Protein derived
carboxyfuorescein (Cf) at N -terminal
In vitro
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

Neuro2A And HeLa Cells

Assay & Model

Cre reporter mouse lines mTmG and Rosa26lacZ
Cre reporter mouse lines mTmG and Rosa26lacZ

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Protein derived
FITC dye and Cre protein attached
Showed a strong preference for Neuro2a cells over HeLa cells
In vitro and in vivo
CCCSCTTSSSSCCCCCC
Additional Detail Fields 1 fields
CCCSCTTSSSSCCCCCC