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Peptide record

TPDB64678

Ypep-GFP-Ypep Cell-penetrating Peptides standard
24 amino acids
Basic Information
3D PDB MODEL
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TPDB64678
Ypep-GFP-Ypep
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 24-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, MLCPP 2.0, Peptipedia, and other sources, with an available 3D structural model.
Sequence
YTFGLKTSFNVQYTFGLKTSFNVQ
Physicochemical Analysis
C132H192N30O37
ARDCEHIMPW
FT
2791.16
9.97
2
0
10
+2
-2.56
-0.100
56.67
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
2980
106.77
12
Residue Composition
number
0
A
0
R
2
N
0
D
0
C
0
E
2
Q
2
G
0
H
0
I
2
L
2
K
0
M
4
F
0
P
2
S
4
T
0
W
2
Y
2
V
Amino Acid Distribution
A: 0 R: 0 N: 2 D: 0 C: 0 E: 0 Q: 2 G: 2 H: 0 I: 0 L: 2 K: 2 M: 0 F: 4 P: 0 S: 2 T: 4 W: 0 Y: 2 V: 2
Chemical Descriptors
24
C132H192N30O37
2791.16
9.97
+2
-2.56
-0.100
Free
L
Linear
Free
N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Human prostate adenocarcinoma cells (PC-3), Human prostate carcinoma cells (LNCaP), human embryonic lung fibroblasts (MRC-9),human spleen fibroblasts (Hs 697.Sp) and HEK293T cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
Protein (eGFP), Phage
Higher uptake of GFP (~3 fold) at 100 nM concentration
Endocytic pathway
In vitro
CCCSCCCSSSSSCCSSSTTTTCCC
Additional Detail Fields 1 fields
CCCSCCCSSSSSCCSSSTTTTCCC