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Peptide record

TPDB64677

Ypep-GFP Cell-penetrating Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB64677
Ypep-GFP
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 Peptipedia
standard
No
A 12-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0 and Peptipedia, with an available 3D structural model.
Sequence
YTFGLKTSFNVQ
Physicochemical Analysis
C66H97N15O19
ARDCEHIMPW
FT
1404.59
9.74
1
0
5
+1
-1.28
-0.100
56.67
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
1490
106.08
6
Residue Composition
number
0
A
0
R
1
N
0
D
0
C
0
E
1
Q
1
G
0
H
0
I
1
L
1
K
0
M
2
F
0
P
1
S
2
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 1 G: 1 H: 0 I: 0 L: 1 K: 1 M: 0 F: 2 P: 0 S: 1 T: 2 W: 0 Y: 1 V: 1
Chemical Descriptors
12
C66H97N15O19
1404.59
9.74
+1
-1.28
-0.100
Free
L
Linear
Free
N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Human prostate adenocarcinoma cells (PC-3), Human prostate carcinoma cells (LNCaP), human embryonic lung fibroblasts (MRC-9),human spleen fibroblasts (Hs 697.Sp) and HEK293T cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
Protein (eGFP), Phage
Modest uptake of GFP into the cell.
Endocytic pathway
In vitro
CCSCCCCCCCCC
Additional Detail Fields 1 fields
CCSCCCCCCCCC