Back to search

Peptide record

TPDB64658

Peptide 6 Cell-penetrating Peptides standard
37 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB64658
Peptide 6
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 37-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
YQQYQDATADEQGGSGSLDPETGEYLYGRKKRRQRRR
Physicochemical Analysis
C183H288N62O63
NCHIMFWV
R
4364.68
9.70
8
6
8
+2
15.31
-1.997
26.49
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
5960
136.55
13
Residue Composition
number
2
A
6
R
0
N
3
D
0
C
3
E
5
Q
5
G
0
H
0
I
2
L
2
K
0
M
0
F
1
P
2
S
2
T
0
W
4
Y
0
V
Amino Acid Distribution
A: 2 R: 6 N: 0 D: 3 C: 0 E: 3 Q: 5 G: 5 H: 0 I: 0 L: 2 K: 2 M: 0 F: 0 P: 1 S: 2 T: 2 W: 0 Y: 4 V: 0
Chemical Descriptors
37
C183H288N62O63
4364.68
9.70
+2
15.31
-1.997
Free
L
Linear
Free
N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)N)C(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

SH-SY5Y Cells And Tau-Egfp Over-Expressed SH-SY5Y Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Chimeric
Poly-D-arginine was more beneficial than the TAT sequence (compare peptide 1 to peptide 6).
In vitro
CCCCCCSSSCTTTTCCCSCHHHHSSTTTTTSCCCC
Additional Detail Fields 1 fields
CCCCCCSSSCTTTTCCCSCHHHHSSTTTTTSCCCC