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Peptide record

TPDB64646

YNTGH Cell-penetrating Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB64646
YNTGH
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 12-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
YNTGHTPVKLHT
Physicochemical Analysis
C61H94N18O18
ARDCEQIMFSW
T
1367.53
9.74
3
0
3
+1
2.78
-0.933
56.67
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
1490
108.96
5
Residue Composition
number
0
A
0
R
1
N
0
D
0
C
0
E
0
Q
1
G
2
H
0
I
1
L
1
K
0
M
0
F
1
P
0
S
3
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 2 I: 0 L: 1 K: 1 M: 0 F: 0 P: 1 S: 0 T: 3 W: 0 Y: 1 V: 1
Chemical Descriptors
12
C61H94N18O18
1367.53
9.74
+1
2.78
-0.933
Free
L
Linear
Free
N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Mc3T3-E1 Cell Line, Caco-2 Cells,

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Phage Display
eGFP at C terminus
High uptake compared to the unmodified negative control eGFP in MC3TS-E1 cells but no uptake in Caco-2 cells
In vitro
CCSSCCSSSSCC
Additional Detail Fields 1 fields
CCSSCCSSSSCC