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Peptide record

TPDB64641

C2 Cell-penetrating Peptides standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB64641
C2
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 15-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation N-terminal: Conjugated with CF
Sequence
YLKFIPLKDAIWKIK-NH2
Physicochemical Analysis
C95H150N20O19
RNCEQGHMSTV
K
1876.36
10.31
4
1
9
+3
-0.50
0.187
136.67
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
6990
372.53
1
Residue Composition
number
1
A
0
R
0
N
1
D
0
C
0
E
0
Q
0
G
0
H
3
I
2
L
4
K
0
M
1
F
1
P
0
S
0
T
1
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 3 L: 2 K: 4 M: 0 F: 1 P: 1 S: 0 T: 0 W: 1 Y: 1 V: 0
Chemical Descriptors
15
C95H150N20O19
1876.36
10.31
+3
-0.50
0.187
Amidation
L
Hydrophobic
Cyclic
Conjugated with CF
N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa, Hek293T, Jurkat E6.1 Leukemia Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Cyclic L Hydrophobic
Synthetic
carboxyfluorescein(CF) dye
Cytoplasm
In vitro
CCCGGGGSCSCCCCSSCCIIIIITCC
Additional Detail Fields 1 fields
CCCGGGGSCSCCCCSSCCIIIIITCC