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Peptide record

TPDB64638

Cys‐[4‐Ser‐crotamine(Δ10‐37)] (mini-crotamine) Cell-penetrating Peptides standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB64638
Cys‐[4‐Ser‐crotamine(Δ10‐37)] (mini-crotamine)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 14-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, MLCPP 2.0, Peptipedia, and other sources, with an available 3D structural model.
C-terminal: Amidation N-terminal: Addition of Cysteine
Sequence
YKQSHKKGGKKGSG-NH2
Physicochemical Analysis
C64H108N22O19
ARNDCEILMFPTWV
K
1489.70
10.77
6
0
1
+5
5.85
-2.193
0.00
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
1490
100.02
4
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
1
Q
4
G
1
H
0
I
0
L
5
K
0
M
0
F
0
P
2
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 4 H: 1 I: 0 L: 0 K: 5 M: 0 F: 0 P: 0 S: 2 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
14
C64H108N22O19
1489.70
10.77
+5
5.85
-2.193
Amidation
L
Cationic
Linear
Addition of Cysteine
N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

MCF‐7, Hmec‐1, Ht‐29, Bt‐474 And Ht‐1080 Cell Lines

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
DY676 dye covalently conjugated
The order of internalization was Cys(DY676)‐[HIV‐TAT(47‐56,rR)] = Cys(DY676)‐[4‐Ser‐crotamine(Δ10‐37)] > Cys(DY676)‐[3‐Abu‐maurocalcine(1‐9)] for MCF‐7 and BT‐474 cell lines
In vitro
CCCSSCCTTSCCC
Additional Detail Fields 1 fields
CCCSSCCTTSCCC