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Peptide record

TPDB64636

NrTP-sC18* Cell-penetrating Peptides standard
26 amino acids
Basic Information
3D PDB MODEL
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TPDB64636
NrTP-sC18*
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 26-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation
Sequence
YKQCHKKGGKKGSGGLRKRLRKFRNK-NH2
Physicochemical Analysis
C133H232N50O31S1
ADEIMPTWV
K
3059.68
12.05
13
0
4
+12
9.87
-1.946
30.00
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
1490
48.70
5
Residue Composition
number
0
A
4
R
1
N
0
D
1
C
0
E
1
Q
5
G
1
H
0
I
2
L
8
K
0
M
1
F
0
P
1
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 4 N: 1 D: 0 C: 1 E: 0 Q: 1 G: 5 H: 1 I: 0 L: 2 K: 8 M: 0 F: 1 P: 0 S: 1 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
26
C133H232N50O31S1
3059.68
12.05
+12
9.87
-1.946
Amidation
L
Linear
Free
N[C@@H](Cc1ccccc1)C(=O)/N=C/C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

MCF-7 And HeLa Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Chimeric
5(6)-carboxyfluorescein and Doxorubicin
Cytosol and Nucleoli
Extremely high uptake compared to the CPP sC18*
Direct translocation and endocytosis
In vitro
CCTTSSCCCCC
Additional Detail Fields 1 fields
CCTTSSCCCCC