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Peptide record

TPDB64634

Pep4 Cell-penetrating Peptides modified_plain modified
17 amino acids
Basic Information
3D PDB MODEL
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TPDB64634
Pep4
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
modified_plain
Yes
A 17-aa modified cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation Chemical: X = Dipropylglycine (Dpg), N-terminal tyrosine (Tyr) N-terminal: Acetylation
Sequence
Ac-YKLXLKLXLKXLKLXLK-NH2
Physicochemical Analysis
C81H148N18O15
ARNDCEQGHIMFPSTWV
L
1614.18
10.77
5
0
8
+5
0.09
0.341
160.59
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
1490
92.31
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
7
L
5
K
0
M
0
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 7 K: 5 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
17
C81H148N18O15
1614.18
10.77
+5
0.09
0.341
Amidation
X = Dipropylglycine (Dpg), N-terminal tyrosine (Tyr)
Modified
Amphipathic
Linear
Acetylation
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Huh-7 And HeLa Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Linear Modified Amphipathic
Synthetic
Cy5-labeled pDNA (fLuc and gLuc)
Cytosol
Exhibited higher transfection efficiencies than others at a low N/P ratio
In vitro