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Peptide record

TPDB64629

BBBpS_8 Cell-penetrating Peptides standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB64629
BBBpS_8
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 16-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation N-terminal: Conjugated with CF
Sequence
YKEATSTFTNITYRGT-NH2
Physicochemical Analysis
C82H125N21O28
DCQHLMPWV
T
1853.02
9.56
2
1
5
+1
1.59
-0.850
30.63
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
2980
160.82
9
Residue Composition
number
1
A
1
R
1
N
0
D
0
C
1
E
0
Q
1
G
0
H
1
I
0
L
1
K
0
M
1
F
0
P
1
S
5
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 1 D: 0 C: 0 E: 1 Q: 0 G: 1 H: 0 I: 1 L: 0 K: 1 M: 0 F: 1 P: 0 S: 1 T: 5 W: 0 Y: 2 V: 0
Chemical Descriptors
16
C82H125N21O28
1853.02
9.56
+1
1.59
-0.850
Amidation
L
Hydrophobic
Linear
Conjugated with CF
N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Hebc-5I, Hs68, HeLa, MDA-MB-231 And Hek-293 Cells

Assay & Model

7-weeks old CD1 female mice
7-weeks old CD1 female mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Hydrophobic
Synthetic
CF dye and Ga-radiolabed for in-vivo
Translocation =35.4 ± 8.5
In vitro and in vivo
CCSTTTTHHHHHHHTTCC
Additional Detail Fields 1 fields
CCSTTTTHHHHHHHTTCC