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Peptide record

TPDB64626

Leader peptide(LP) Cell-penetrating Peptides standard
27 amino acids
Basic Information
3D PDB MODEL
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TPDB64626
Leader peptide(LP)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 27-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
YHMMLSALARPASAALRRSFSTSAQNN
Physicochemical Analysis
C125H203N41O38S2
DCEGIKWV
A
2952.36
12.11
4
0
13
+3
0.82
-0.222
65.56
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
1490
50.47
10
Residue Composition
number
6
A
3
R
2
N
0
D
0
C
0
E
1
Q
0
G
1
H
0
I
3
L
0
K
2
M
1
F
1
P
5
S
1
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 6 R: 3 N: 2 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 1 I: 0 L: 3 K: 0 M: 2 F: 1 P: 1 S: 5 T: 1 W: 0 Y: 1 V: 0
Chemical Descriptors
27
C125H203N41O38S2
2952.36
12.11
+3
0.82
-0.222
Free
L
Amphiphilic
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

MCF-7, Bt474, Nci-N87, And MCF-10A Cells

Assay & Model

Female BALB/c nude mice (3–4 weeks old, 16–18 g)
Female BALB/c nude mice (3–4 weeks old, 16–18 g)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphiphilic
Protein derived
anti-HER2 scFv and EGFP
Cytoplasm
LP-scFv-EGFP internalization (41.2% ± 1.0%) was about twice that of scFv-EGFP (20.4% ± 2.4%) in BT474 cells
Endocytosis
In vitro and in vivo
CCCSSSTTCCCTTTTC
Additional Detail Fields 1 fields
CCCSSSTTCCCTTTTC