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Peptide record

TPDB64625

F-Tat-3 Cell-penetrating Peptides modified_plain modified
11 amino acids
Basic Information
3D PDB MODEL
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TPDB64625
F-Tat-3
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
modified_plain
Yes
A 11-aa modified cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation Chemical: Z = APC N-terminal: Conjugated with 6-Carboxyfluorescein (6-Fam)
Sequence
YGZKKRZQRZR-NH2
Physicochemical Analysis
C46H82N20O11
ANDCEHILMFPSTWV
R
1091.28
12.14
5
0
1
+5
4.06
-2.409
0.00
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
1490
136.54
2
Residue Composition
number
0
A
3
R
0
N
0
D
0
C
0
E
1
Q
1
G
0
H
0
I
0
L
2
K
0
M
0
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 1 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
11
C46H82N20O11
1091.28
12.14
+5
4.06
-2.409
Amidation
Z = APC
L
Hybrid (Cyclic and Linear)
Conjugated with 6-Carboxyfluorescein (6-Fam)
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Hybrid (Cyclic and Linear) L
Protein derived
Fluorescein (6FAM) dye
Late Endosomes/Lysosomes
More efficiently than the α-peptide F-Tat
Macropinocytosis
In vitro