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Peptide record

TPDB64620

CTP CTP512 Blood-Brain Barrier Cell-penetrating Peptides standard
11 amino acids
Basic Information
3D PDB MODEL
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TPDB64620
CTP CTP512
Blood-Brain Barrier Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
B3Pred BBPpredict Peptipedia CellPPD CPPsite3.0 PerseuCPP
standard
No
A 11-aa standard natural multi-activity (Blood-Brain Barrier and Cell-penetrating Peptides) peptide sequence curated from B3Pred, BBPpredict, Peptipedia, and other sources, with an available 3D structural model.
Sequence
YGRRARRRRRR
Physicochemical Analysis
C62H115N35O13
NDCEQHILKMFPSTWV
R
1558.82
12.88
8
0
2
+8
5.38
-3.264
9.09
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
1490
95.58
1
Residue Composition
number
1
A
8
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 8 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
11
C62H115N35O13
1558.82
12.88
+8
5.38
-3.264
Free
L
Linear
Linear
Free
Similarity
TyrGlyArgArgAlaArgArgArgArgArgArg
N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)O N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)O
Evidence Records 4 records
Evidence 1 Activity

Activity

Blood-Brain Barrier

Assay & Model

Origin/Source

Source & Reference

NA
B3Pdb
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Assay & Model

Mice (Kunming species, 22 g, sex-matched)
Mice (Kunming species, 22 g, sex-matched)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Gamma-aminobutyric acid (GABA)
In vivo
CCGGGCSTTTC
Evidence 3 Activity

Activity

Cell-penetrating Peptides

Assay & Model

Mice (male, 18−26 g, Kunming species)
Mice (male, 18−26 g, Kunming species)

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
γ-aminobutyric acid (GABA)
GABA at dose of 50mg/kg essentially penetrated, as expected, into the brain tissue (474 ± 33 μg/g) and so did GABA−CPP (446 ± 44 μg/g) at a dose of 10 mg/kg
In vivo
CCGGGGGGGGGGHHHHTTSCCC
Evidence 4 Activity

Activity

Cell-penetrating Peptides

Target

HeLa Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Synthetic
Alexa fluor® 488 at Lys
Cytoplasm
Mean fluorescence emission followed the trend: MCoTI-II < MCo-RM1 < MCo-CTP ~ TAT < CTP512
In vitro
CCSCCC
Additional Detail Fields 1 fields
CCGGGCSTTTC CCGGGGGGGGGGHHHHTTSCCC CCSCCC