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Peptide record

TPDB64612

TAT Cell-penetrating Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB64612
TAT
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 12-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
YGRKKRRRQRRR
Physicochemical Analysis
C70H130N36O15
ANDCEHILMFPSTWV
R
1716.03
12.80
9
0
1
+9
7.30
-3.708
0.00
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
1490
86.83
2
Residue Composition
number
0
A
7
R
0
N
0
D
0
C
0
E
1
Q
1
G
0
H
0
I
0
L
2
K
0
M
0
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 7 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 1 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
12
C70H130N36O15
1716.03
12.80
+9
7.30
-3.708
Free
L
Cationic
Linear
Free
N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Primary Neurons, Hek293 Cells

Assay & Model

Drosophila melanogaster
Drosophila melanogaster

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
Orf9b peptide
TAT-Orf9b10-18_78–95 penetrates the cellular membrane and inhibits MARK4 activity.
In vitro and in vivo
CCSCBTTBCCC
Additional Detail Fields 1 fields
CCSCBTTBCCC