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Peptide record

TPDB64601

Tat-NTS Cell-penetrating Peptides standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB64601
Tat-NTS
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 21-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation Chemical: FITC-labeled
Sequence
YGRKKRRQRRRRSFPHLRRVF-NH2
Physicochemical Analysis
C125H211N53O25
ANDCEIMTW
R
2856.39
12.95
12
0
5
+11
7.71
-2.167
32.38
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
1490
52.16
3
Residue Composition
number
0
A
9
R
0
N
0
D
0
C
0
E
1
Q
1
G
1
H
0
I
1
L
2
K
0
M
2
F
1
P
1
S
0
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 9 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 1 H: 1 I: 0 L: 1 K: 2 M: 0 F: 2 P: 1 S: 1 T: 0 W: 0 Y: 1 V: 1
Chemical Descriptors
21
C125H211N53O25
2856.39
12.95
+11
7.71
-2.167
Amidation
FITC-labeled
L
Linear
Free
N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Primary Cultured Neurons.

Assay & Model

Middle cerebral artery occlusion (MCAO) Adult C57BL/6 male mice model
Middle cerebral artery occlusion (MCAO) Adult C57BL/6 male mice model

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Fusogenic
NTS sequence of ANXA1 (annexin A1)
In vitro and in vivo
CCSCGGGGGTCSSCCCCCC
Additional Detail Fields 1 fields
CCSCGGGGGTCSSCCCCCC