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Peptide record

TPDB64599

TAT-PLP Cell-penetrating Peptides standard
23 amino acids
Basic Information
3D PDB MODEL
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TPDB64599
TAT-PLP
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 23-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: Protein linking peptide (PLP) N-terminal: Conjugated with FITC
Sequence
YGRKKRRQRRRRRRQQQQQQRRR
Physicochemical Analysis
C130H238N68O32
ANDCEHILMFPSTWV
R
3265.76
13.10
14
0
1
+14
14.83
-3.826
0.00
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
1490
45.62
8
Residue Composition
number
0
A
12
R
0
N
0
D
0
C
0
E
7
Q
1
G
0
H
0
I
0
L
2
K
0
M
0
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 12 N: 0 D: 0 C: 0 E: 0 Q: 7 G: 1 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
23
C130H238N68O32
3265.76
13.10
+14
14.83
-3.826
Free
Protein linking peptide (PLP)
L
Linear
Conjugated with FITC
N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa Cells And Fibroblasts Cells

Assay & Model

Five weeks-old BALB/c mice
Five weeks-old BALB/c mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Chimeric
β-galactosidase and Cre recombinase
TAT-conjugated enzyme was not delivered as efficiently as the AA3H-conjugated one.
In vitro and in vivo
CCSCGGGSSGGGGGGHHHHTTCC
Additional Detail Fields 1 fields
CCSCGGGSSGGGGGGHHHHTTCC