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Peptide record

TPDB64595

PEP-3 Cell-penetrating Peptides standard
25 amino acids
Basic Information
3D PDB MODEL
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TPDB64595
PEP-3
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 25-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, MLCPP 2.0, Peptipedia, and other sources, with an available 3D structural model.
Sequence
YGRKKRRQRRRQRRRPTAPLSPMSP
Physicochemical Analysis
C131H232N56O32S1
NDCEHIFWV
R
3135.70
12.95
11
0
4
+11
10.74
-2.328
19.60
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
1490
47.52
6
Residue Composition
number
1
A
9
R
0
N
0
D
0
C
0
E
2
Q
1
G
0
H
0
I
1
L
2
K
1
M
0
F
4
P
2
S
1
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 9 N: 0 D: 0 C: 0 E: 0 Q: 2 G: 1 H: 0 I: 0 L: 1 K: 2 M: 1 F: 0 P: 4 S: 2 T: 1 W: 0 Y: 1 V: 0
Chemical Descriptors
25
C131H232N56O32S1
3135.70
12.95
+11
10.74
-2.328
Free
L
Cationic
Linear
Free
N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

GSC lines (G166, GliNS2, G144, G179), OB1 and TG10 cells

Assay & Model

Albino wistar rats
Albino wistar rats

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
Lower uptake efficiency
In vitro and in vivo
CTTCGGGGGGGGCCCSSCCSCSSCC
Additional Detail Fields 1 fields
CTTCGGGGGGGGCCCSSCCSCSSCC