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Peptide record

TPDB64592

TAT-S Cell-penetrating Peptides standard
27 amino acids
Basic Information
3D PDB MODEL
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TPDB64592
TAT-S
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 27-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
YGRKKRRQRRRPPNTTTLSNLPTNVRN
Physicochemical Analysis
C137H239N55O39
ADCEHIMFW
R
3280.75
12.80
9
0
4
+9
9.97
-2.041
39.63
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
1490
45.42
11
Residue Composition
number
0
A
7
R
4
N
0
D
0
C
0
E
1
Q
1
G
0
H
0
I
2
L
2
K
0
M
0
F
3
P
1
S
4
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 7 N: 4 D: 0 C: 0 E: 0 Q: 1 G: 1 H: 0 I: 0 L: 2 K: 2 M: 0 F: 0 P: 3 S: 1 T: 4 W: 0 Y: 1 V: 1
Chemical Descriptors
27
C137H239N55O39
3280.75
12.80
+9
9.97
-2.041
Free
L
Linear
Free
N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Hek293T-Cells, Cortical Neurons (From Cerebral Cortex Of 19-Day-Old Wistar Rat Embryos)

Assay & Model

Mice (Adult male Balb/c mice (25–30 g))model of focal cerebral ischemia
Mice (Adult male Balb/c mice (25–30 g))model of focal cerebral ischemia

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Chimeric
FITC-labeled and rat Kidins220 amino acid sequence
In vitro and in vivo
CCCCSSCCC
Additional Detail Fields 1 fields
CCCCSSCCC