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Peptide record

TPDB64582

TFL518 Cell-penetrating Peptides standard
25 amino acids
Basic Information
3D PDB MODEL
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TPDB64582
TFL518
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 25-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation N-terminal: Acetylation
Sequence
Ac-YGRKKRRQRRRITNSQLKPDTFVQH-NH2
Physicochemical Analysis
C136H230N52O36
ACEMW
R
3169.65
12.41
10
1
5
+8
10.18
-1.984
42.80
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
1490
47.01
8
Residue Composition
number
0
A
6
R
1
N
1
D
0
C
0
E
3
Q
1
G
1
H
1
I
1
L
3
K
0
M
1
F
1
P
1
S
2
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 6 N: 1 D: 1 C: 0 E: 0 Q: 3 G: 1 H: 1 I: 1 L: 1 K: 3 M: 0 F: 1 P: 1 S: 1 T: 2 W: 0 Y: 1 V: 1
Chemical Descriptors
25
C136H230N52O36
3169.65
12.41
+8
10.18
-1.984
Amidation
L
Linear
Acetylation
N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)N)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)O)C(=O)NCC(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Rat Primary Neurons From 18-Day-Old Wistar Rat Embryos (E18)

Assay & Model

Ischemia model using cerebral cortex of adult male Balb/cOlaHsd mice (25–30 g 8–12 weeks)
Ischemia model using cerebral cortex of adult male Balb/cOlaHsd mice (25–30 g 8–12 weeks)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Chimeric
Receptor mediated endocytosis
In vitro and in vivo
CCSCGGGGTTSSSSSSCCCBTTBC
Additional Detail Fields 1 fields
CCSCGGGGTTSSSSSSCCCBTTBC