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Peptide record

TPDB64581

TFL457 Blood-Brain Barrier Cell-penetrating Peptides standard
25 amino acids
Basic Information
3D PDB MODEL
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TPDB64581
TFL457
Blood-Brain Barrier Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
BBPpredict CPPsite3.0
standard
No
A 25-aa standard natural multi-activity (Blood-Brain Barrier and Cell-penetrating Peptides) peptide sequence curated from BBPpredict and CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation N-terminal: Acetylation
Sequence
Ac-YGRKKRRQRRRHSKFGMKGPASVIS-NH2
Physicochemical Analysis
C128H220N50O31S1
NDCELTW
R
2987.53
12.71
11
0
6
+10
8.52
-1.624
31.20
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
1490
49.87
5
Residue Composition
number
1
A
6
R
0
N
0
D
0
C
0
E
1
Q
3
G
1
H
1
I
0
L
4
K
1
M
1
F
1
P
3
S
0
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 1 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 3 H: 1 I: 1 L: 0 K: 4 M: 1 F: 1 P: 1 S: 3 T: 0 W: 0 Y: 1 V: 1
Chemical Descriptors
25
C128H220N50O31S1
2987.53
12.71
+10
8.52
-1.624
Amidation
L
Linear
Acetylation
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Rat Primary Neurons From 18-Day-Old Wistar Rat Embryos (E18)

Assay & Model

Ischemia model using cerebral cortex of adult male Balb/cOlaHsd mice (25–30 g 8–12 weeks)
Ischemia model using cerebral cortex of adult male Balb/cOlaHsd mice (25–30 g 8–12 weeks)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Linear L
Chimeric
Receptor mediated endocytosis
In vitro and in vivo