Back to search

Peptide record

TPDB64580

TAT-C1aB Cell-penetrating Peptides standard
20 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB64580
TAT-C1aB
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 20-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: FITC-labeled at C terminus
Sequence
YGRKKRRQRRRHLSPNKWKW
Physicochemical Analysis
C122H198N48O25
ADCEIMFTV
R
2737.22
12.71
11
0
4
+10
6.17
-2.745
19.50
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
12490
456.30
4
Residue Composition
number
0
A
6
R
1
N
0
D
0
C
0
E
1
Q
1
G
1
H
0
I
1
L
4
K
0
M
0
F
1
P
1
S
0
T
2
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 1 D: 0 C: 0 E: 0 Q: 1 G: 1 H: 1 I: 0 L: 1 K: 4 M: 0 F: 0 P: 1 S: 1 T: 0 W: 2 Y: 1 V: 0
Chemical Descriptors
20
C122H198N48O25
2737.22
12.71
+10
6.17
-2.745
Free
FITC-labeled at C terminus
L
Linear
Free
NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Assay & Model

Young-adult C57BL/6J male mice (24 –29 g)
Young-adult C57BL/6J male mice (24 –29 g)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Fusogenic
Kv2.1 C terminus (C1aB)
TAT-C1aB-FitC (6 nmol/g) were found to present increased fluorescent signal throughout the brain, when compared with animals injected with the nonfluorescent TAT-C1aB
In vivo
CCCCGGGTTSSSSSSSSCC
Additional Detail Fields 1 fields
CCCCGGGTTSSSSSSSSCC