Back to search

Peptide record

TPDB64578

Histidine tagged TAT Cell-penetrating Peptides standard
17 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB64578
Histidine tagged TAT
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 17-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Conjugated with FITC Chemical: Liposomes
Sequence
YGRKKRRQRRRHHHHHH
Physicochemical Analysis
C100H160N50O20
ANDCEILMFPSTWV
RH
2382.69
12.71
14
0
1
+9
12.25
-3.482
0.00
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
1490
62.53
2
Residue Composition
number
0
A
6
R
0
N
0
D
0
C
0
E
1
Q
1
G
6
H
0
I
0
L
2
K
0
M
0
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 1 H: 6 I: 0 L: 0 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
17
C100H160N50O20
2382.69
12.71
+9
12.25
-3.482
Conjugated with FITC
Liposomes
L
Linear
Free
N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Rat Skin (From Cd®(Sd) Hrbi Hairless Rats ) And Porcine Ears Skin (From Yorkshire Marine Pigs, Male, Weighing About 200 Lb)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Doxorubicin
Dox TAT liposomes showed 7.0 and 4.5-fold more red fluorescence than dox solution and physical mixture, respectively.
Ex vivo
CCCSSSCCCC
Additional Detail Fields 1 fields
CCCSSSCCCC