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Peptide record

TPDB64577

TAT-PBD-PTM Cell-penetrating Peptides standard
25 amino acids
Basic Information
3D PDB MODEL
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TPDB64577
TAT-PBD-PTM
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 25-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
YGRKKRRQRRRGVLYVGSKTRRRRG
Physicochemical Analysis
C132H237N59O31
ANDCEHIMFPW
R
3146.71
12.77
13
0
5
+13
9.66
-2.148
38.80
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
2980
94.70
5
Residue Composition
number
0
A
10
R
0
N
0
D
0
C
0
E
1
Q
4
G
0
H
0
I
1
L
3
K
0
M
0
F
0
P
1
S
1
T
0
W
2
Y
2
V
Amino Acid Distribution
A: 0 R: 10 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 4 H: 0 I: 0 L: 1 K: 3 M: 0 F: 0 P: 0 S: 1 T: 1 W: 0 Y: 2 V: 2
Chemical Descriptors
25
C132H237N59O31
3146.71
12.77
+13
9.66
-2.148
Free
L
Linear
Free
N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)N)C(=O)/N=C/C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Sk-N-Sh Neuroblastoma Cells Or Hek293T Cells Primary Neurons

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Chimeric
Rhodamine-labelled at N terminus
Dose- and time-dependent internalization
In vitro
CCCCCCGGGCCSSSTTCSSSSSSCTTTSSSCSSTTCC
Additional Detail Fields 1 fields
CCCCCCGGGCCSSSTTCSSSSSSCTTTSSSCSSTTCC