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Peptide record

TPDB64574

TAT-NBD Cell-penetrating Peptides standard
23 amino acids
Basic Information
3D PDB MODEL
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TPDB64574
TAT-NBD
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 Peptipedia PerseuCPP
standard
No
A 23-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, Peptipedia, and PerseuCPP, with an available 3D structural model.
Sequence
YGRKKRRQRRRGTALDWSWLQTE
Physicochemical Analysis
C128H207N47O34
NCHIMFPV
R
2948.35
12.12
8
2
6
+6
5.75
-1.978
38.26
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
12490
423.63
6
Residue Composition
number
1
A
6
R
0
N
1
D
0
C
1
E
2
Q
2
G
0
H
0
I
2
L
2
K
0
M
0
F
0
P
1
S
2
T
2
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 6 N: 0 D: 1 C: 0 E: 1 Q: 2 G: 2 H: 0 I: 0 L: 2 K: 2 M: 0 F: 0 P: 0 S: 1 T: 2 W: 2 Y: 1 V: 0
Chemical Descriptors
23
C128H207N47O34
2948.35
12.12
+6
5.75
-1.978
L
Linear
N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(=O)O)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

PC- 3M-1E8, MDA-MB-231, MCF-7 and PC-3M-2B4 cells

Assay & Model

BALB/c nu/nu mice
BALB/c nu/nu mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Peptide (TMTP1)
TAT-NBD displayed strong non- specific affinity to both highly and lowly metastatic tumor cells
In vitro and in vivo
CCCCGGGSSTTSCCSCCSSSSCC
Additional Detail Fields 1 fields
CCCCGGGSSTTSCCSCCSSSSCC