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Peptide record

TPDB64573

TAT Cell-penetrating Peptides standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB64573
TAT
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 14-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
YGRKKRRQRRRGSG
Physicochemical Analysis
C71H129N35O18
ANDCEHILMFPTWV
R
1761.03
12.71
8
0
1
+8
6.64
-2.971
0.00
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
1490
84.61
3
Residue Composition
number
0
A
6
R
0
N
0
D
0
C
0
E
1
Q
3
G
0
H
0
I
0
L
2
K
0
M
0
F
0
P
1
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 3 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 0 S: 1 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
14
C71H129N35O18
1761.03
12.71
+8
6.64
-2.971
Free
L
Cationic
Linear
Free
N[C@@H](Cc1ccccc1)C(=O)/N=C/C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Veroe6 Cells , Mrc5 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
wild-type NOTCH4 and DYRK1B-derived peptides
TAT-NOTCH4 peptide was readily internalized, and the uptake of the TAT-tagged-DYRK1B peptide was much less efficient, potentially explaining the low efficacy of the peptide.
In vitro
CCTTSSCCCCC
Additional Detail Fields 1 fields
CCTTSSCCCCC